Unraveling the mystery of the hygiene hypothesis through Helicobacter pylori infection.
نویسندگان
چکیده
Epidemiological studies have revealed an inverse association between Helicobacter pylori infection and the incidence of allergic asthma. This association is consistent with the hygiene hypothesis, which posits that exposure to microbes early in life prevents the later development of allergic diseases, and has been reproduced in mouse models of asthma. In this issue of the JCI, Oertli and colleagues report that H. pylori infection in neonates elicits tolerogenic DCs that produce IL-18, which drive the generation of Tregs that subsequently protect the mice from allergic asthma. This finding strengthens the intriguing link between pathogen exposure and allergic disease.
منابع مشابه
Helicobacter, Hygiene, Atopy, and Asthma
The hygiene hypothesis links environmental and microbial exposures in early life to the prevalence of atopy, allergy, and asthma. Helicobacter pylori infection is typically acquired in childhood and acquisition of the infection is associated with poor household hygiene. Some population surveys have shown an inverse association between H. pylori infection and atopy, allergy, and asthma leading t...
متن کاملHelicobacter pylori infection in a low prevalence population – what can we learn?
Helicobacter pylori (H. pylori) infection is etiologically associated with gastric cancer and peptic ulcer diseases which are both important public health burdens and which could be largely eliminated by H. pylori eradication. However, some investigators urge caution based on the hypothesis that eradication of H. pylori may result in an increase in the incidence of gastroesophageal reflux disea...
متن کاملHelicobacter Pylori Seropositivity among Patients with Hyperemesis Gravidarum
Background: There are also reports from other parts of the world indicating the presence of significant association of H. pylori infection and hyperemesis gravidarum, a bothersome condition that affects pregnant women. Objective: To test the hypothesis that whether H. pylori infection is associated with hyperemesis gravidarum among Iranian H.P carriers. Methods: From November 1999 to February...
متن کاملFood Allergy and Helicobacter pylori Infection: A Systematic Review
INTRODUCTION Based on the hygiene hypothesis, a low prevalence of Helicobacter pylori (H. pylori) infection may explain the recent high prevalence of allergic diseases including food allergy. However, there are very few studies that investigate the relationship between H. pylori and food allergy. SUMMARY We searched for PubMed, Ovid Medline and the Cochrane library for relevant articles publi...
متن کاملHelicobacter pylori serology in pregnant women with hyperemesis gravidarum
Introduction: Hyperemesis gravidarum (HG) is a relatively common problem. Despite its obvious effect on quality of life in pregnancy, it can lead to dangerous complications. This study was conducted to evaluate the hypothesis that there is meaningful association between hyperemesis gravidarum and gastric infection with Helicobacter pylori. Methods: This is a prospective case-control study in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 122 3 شماره
صفحات -
تاریخ انتشار 2012